Applied Therapeutics Inc
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Applied Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing a pipeline of product candidates against validated molecular targets in indications of high unmet medical need. The Company’s molecular target is aldose reductase (AR), an enzyme that converts glucose to sorbitol under oxidative stress conditions. The Company’s product candidates include AT-007, AT-001, and AT-003. Its AT-007 is a central nervous system (CNS) penetrant ARI for the treatment of CNS rare diseases, including Galactosemia, sorbitol dehydrogenase (SORD) deficiency, and PMM2-CDG. AT-001 is an aldose reductase inhibitor (ARI) with exposure and nerve permeability. AT-001 is being developed for the treatment of diabetic cardiomyopathy (DbCM), a fatal fibrosis of the heart. Its AT-003 is an ARI designed to cross through the back of the eye when dosed orally. AT-003 is developed for the treatment of diabetic retinopathy (DR).
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